文章目录

旧与新：早幼粒细胞白血病锌指蛋白的上游与下游

Old versus new: upstream and downstream of promyelocytic leukemia zinc finger protein

原文发布日期：2025-05-10

英文摘要：

摘要翻译：

原文链接：

文章：

旧与新：早幼粒细胞白血病锌指蛋白的上游与下游

Old versus new: upstream and downstream of promyelocytic leukemia zinc finger protein

原文发布日期：2025-05-10

英文摘要：

Promyelocytic leukemia zinc finger (PLZF) is a member of the zinc finger protein family and has been extensively studied due to its crucial role in influencing stem cell self-renewal, spermatogenesis, T cell differentiation, tumorigenesis, and development. Its function is regulated by multidimensional and multilevel regulation. Recent studies have explored the mechanism of action of PLZF in different diseases and related treatment strategies. This study aimed to summarize the regulatory mechanisms underlying PLZF expression and function, and update the latest PLZF regulatory targets and interacting molecules. We also summarized the mechanism by which PLZF promoted the transcriptional activation of target genes, besides its role as a transcriptional repressor. This study revealed a more detailed upstream and downstream regulatory mechanism of PLZF, providing directions for future research.

摘要翻译：

早幼粒细胞白血病锌指蛋白（PLZF）作为锌指蛋白家族成员，因其在调控干细胞自我更新、精子发生、T细胞分化、肿瘤形成及发育过程中的关键作用而被广泛研究。该蛋白功能受到多维度和多层次的精密调控。近期研究深入探讨了PLZF在不同疾病中的作用机制及相关治疗策略。本研究旨在系统总结PLZF表达与功能的调控机制，更新其最新调控靶点及相互作用分子，同时阐释了PLZF除作为转录抑制因子外促进靶基因转录激活的作用机制。本研究揭示了更精细的PLZF上下游调控网络，为未来研究方向提供了重要指引。