文章：

TSPAN1通过抑制NF-kB信号通路抑制鼻咽癌转移

TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling 

原文发布日期：2023-12-22 

英文摘要：

Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration and invasion, as well as, the in vivo metastasis of NPC cells via interacting with the IKBB protein. In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. These results uncovered the suppressive role of TSPAN1 against NF-kB signaling in NPC cells for preventing NPC metastasis. Its therapeutic value warrants further investigation. 

摘要翻译： 

鼻咽癌（NPC）起源于鼻咽部上皮细胞，是中国南方和东南亚地区常见的恶性肿瘤。尽管该肿瘤对放疗和化疗敏感，但其转移仍是导致患者死亡的主要原因。本研究发现，跨膜蛋白四跨膜蛋白1（TSPAN1）通过与IKBB蛋白相互作用，显著抑制鼻咽癌细胞的体外迁移侵袭能力及体内转移能力。此外，TSPAN1在过表达的鼻咽癌细胞中对防止NF-κB通路过度激活具有关键作用。临床分析进一步显示，TSPAN1表达水平降低与鼻咽癌转移及患者不良预后密切相关。这些结果揭示了TSPAN1通过抑制NF-κB信号通路阻止鼻咽癌转移的分子机制，其治疗价值值得进一步研究。

原文链接：

TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling