文章目录

转铁蛋白受体参与宫颈癌HIF-1信号通路的研究

Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer

原文发布日期：2019-01-17

英文摘要：

摘要翻译：

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文章：

转铁蛋白受体参与宫颈癌HIF-1信号通路的研究

Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer

原文发布日期：2019-01-17

英文摘要：

Cervical cancer is one of the most prevalent gynecologic malignancies and has remained an intractable cancer over the past decades. We analyzed the aberrant expression patterns of cervical cancer using RNA-Seq data from The Cancer Genome Atlas (TCGA). A total of 3352 differently expressed genes (DEGs) were identified in 306 cervical cancer samples compared with 3 control samples, with 1401 genes upregulated and 1951 downregulated. Under Kaplan–Meier analysis, 76 out of these DEGs with a significantly different survival rate between patients with high and low expression groups were picked out and uploaded to perform Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, which identified a transferrin receptor (TFRC)-involved HIF-1 signaling pathway (p < 0.05). Clinical data analysis showed that high TFRC expression in cervical cancers was associated with incrementally advanced stage, tumor status, and lymph nodes (all p-values <0.05), while multivariate analysis revealed that TFRC remained an independent prognostic variable for poor overall survival. In conclusion, our data indicated
that the TFRC-involved HIF-1 signaling pathway may play a crucial role in cervical cancer.

摘要翻译：

宫颈癌是最常见的妇科恶性肿瘤之一，在过去数十年中仍是一种难治性癌症。我们利用癌症基因组图谱（TCGA）的RNA测序数据分析了宫颈癌的异常表达模式。通过306例宫颈癌样本与3例对照样本的比较，共鉴定出3352个差异表达基因（DEGs），其中1401个基因上调，1951个基因下调。通过Kaplan-Meier分析筛选出76个在高/低表达组间生存率存在显著差异的DEGs，经京都基因与基因组百科全书（KEGG）通路富集分析发现，这些基因显著富集于转铁蛋白受体（TFRC）参与的HIF-1信号通路（p<0.05）。临床数据分析显示，TFRC高表达与宫颈癌临床分期进展、肿瘤状态恶化及淋巴结转移显著相关（所有p值<0.05），多变量分析表明TFRC是总体生存率不佳的独立预后因素。我们的研究结果表明，TFRC参与的HIF-1信号通路可能在宫颈癌发展中起关键作用。