文章：

微管蛋白的翻译后修饰：它们在癌症中的作用和信号分子的调节

Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules 

原文发布日期：2021-10-20 

英文摘要：

Microtubules play an important role in regulating several vital cellular activities, including cell division and tissue organization, through their dynamic protofilament network. In addition to forming the cytoskeleton, microtubules regulate the intracellular trafficking of cytoplasmic components and various signaling molecules, depending on the presence of post-transitional modifications (PTMs) and binding proteins. Accumulating evidence indicates the significant role of microtubule PTMs on cancer behavior. The PTMs that frequently occur on microtubules include acetylation, detyrosination, tyrosination, polyglutamylation, and polyglycylation. Alterations in these PTMs cause global effects on intracellular signal transduction, strongly linked to cancer pathogenesis. This review provides an update on the role of microtubule PTMs in cancer aggressiveness, particularly regarding cell death, sensitivity to chemotherapy, cell migration, and invasion. Additionally, it provides a mechanistic explanation of the molecular signaling pathways involved. This information might prove useful for predictive or therapeutic purposes. 

摘要翻译：

微管通过其动态的原丝纤维网络，在调节细胞分裂和组织构成等多种重要细胞活动中发挥关键作用。除构成细胞骨架外，微管还依赖翻译后修饰（PTMs）和结合蛋白的存在，调控细胞质组分及多种信号分子的细胞内运输。越来越多证据表明，微管PTMs对癌症生物学行为具有重要影响。微管上常见的PTMs包括乙酰化、去酪氨酸化、酪氨酸化、多聚谷氨酰化和多聚甘氨酰化。这些修饰的改变会对细胞内信号转导产生全局性影响，与癌症发病机制密切相关。本综述重点探讨微管PTMs在癌症侵袭性（特别是细胞死亡、化疗敏感性、细胞迁移和侵袭方面）的最新研究进展，并对相关分子信号通路机制进行阐释，这些发现可能为癌症预测和治疗提供新思路。

原文链接：

Post-translational modifications of tubulin: their role in cancers and the regulation of signaling molecules