文章：

肿瘤来源外泌体LncRNA在肿瘤转移中的作用

The role of tumor-derived exosomal LncRNA in tumor metastasis 

原文发布日期：2025-02-26 

英文摘要：

Tumor metastasis regulated by multiple complicated pathways is closely related to variations in the tumor microenvironment (TME). Exosomes can regulate the TME through various mechanisms. Exosomes derived from tumor cells carry a variety of substances, including long non-coding RNAs (lncRNAs), play important roles in intercellular communication and act as critical determinants influencing tumor metastasis. In this review, we elaborate on several pivotal processes through which lncRNAs regulate tumor metastasis, including the regulation of epithelial‒mesenchymal transition, promotion of angiogenesis and lymphangiogenesis, enhancement of the stemness of tumor cells, and evasion of immune clearance. Additionally, we comprehensively summarized a diverse array of potential tumor-derived exosomal lncRNA biomarkers to facilitate accurate diagnosis and prognosis in a clinical setting. 

摘要翻译：

受多种复杂通路调控的肿瘤转移与肿瘤微环境（TME）的变化密切相关。外泌体可通过多种机制调节TME。肿瘤细胞来源的外泌体携带长链非编码RNA（lncRNA）等多种物质，在细胞间通讯中发挥重要作用，是影响肿瘤转移的关键决定因素。本文详细阐述了lncRNA调控肿瘤转移的几个关键过程，包括调控上皮-间质转化、促进血管生成和淋巴管生成、增强肿瘤细胞干性以及逃避免疫清除。此外，我们全面总结了多种潜在的肿瘤源性外泌体lncRNA生物标志物，以促进临床环境中的精准诊断和预后评估。

原文链接：

The role of tumor-derived exosomal LncRNA in tumor metastasis