文章：

NONO的多效性：癌症中关键生物通路的核心调控因子

The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers 

原文发布日期：2024-03-16 

英文摘要：

NONO is a member of the Drosophila behavior/human splicing (DBHS) family of proteins. NONO is a multifunctional protein that acts as a “molecular scaffold” to carry out versatile biological activities in many aspects of gene regulation, cell proliferation, apoptosis, migration, DNA damage repair, and maintaining cellular circadian rhythm coupled to the cell cycle. Besides these physiological activities, emerging evidence strongly indicates that NONO-altered expression levels promote tumorigenesis. In addition, NONO can undergo various post-transcriptional or post-translational modifications, including alternative splicing, phosphorylation, methylation, and acetylation, whose impact on cancer remains largely to be elucidated. Overall, altered NONO expression and/or activities are a common feature in cancer. This review provides an integrated scenario of the current understanding of the molecular mechanisms and the biological processes affected by NONO in different tumor contexts, suggesting that a better elucidation of the pleiotropic functions of NONO in physiology and tumorigenesis will make it a potential therapeutic target in cancer. In this respect, due to the complex landscape of NONO activities and interactions, we highlight caveats that must be considered during experimental planning and data interpretation of NONO studies. 

摘要翻译： 

NONO是果蝇行为/人类剪接（DBHS）蛋白家族的成员。作为一种多功能蛋白质，NONO扮演着"分子支架"的角色，在基因调控、细胞增殖、凋亡、迁移、DNA损伤修复以及与细胞周期耦合的细胞昼夜节律维持等多种生物学活动中发挥重要作用。除这些生理功能外，新出现的证据强烈表明NONO表达水平的改变会促进肿瘤发生。此外，NONO可经历多种转录后或翻译后修饰，包括可变剪接、磷酸化、甲基化和乙酰化，这些修饰对癌症的影响仍有待进一步阐明。总体而言，NONO表达和/或活性的改变是癌症的常见特征。本综述整合了当前对不同肿瘤背景下NONO影响的分子机制和生物学过程的理解，表明更好阐明NONO在生理和肿瘤发生中的多效性功能，将使其成为癌症的潜在治疗靶点。鉴于此，由于NONO活性和相互作用的复杂性，我们强调了在NONO研究的实验设计和数据解读过程中必须考虑的注意事项。

原文链接：

The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers