文章：

微流体技术在免疫检查点阻断中的应用前景

The future of microfluidics in immune checkpoint blockade 

原文发布日期：2020-10-27 

英文摘要：

Recent advances in microfluidic techniques have enabled researchers to study sensitivities to immune checkpoint therapy, to determine patients’ response to particular antibody treatment. Utilization of this technology is helpful in antibody discovery and in the design of personalized medicine. A variety of microfluidic approaches can provide several functions in processes such as immunologic, genomic, and/or transcriptomic analysis with the aim of improving the efficacy and coverage of immunotherapy, particularly immune checkpoint blockade (ICB). To achieve this requires researchers to overcome the challenges in the current state of the technology. This review looks into the advancements in microfluidic technologies applied to researches on immune checkpoint blockade treatment and its potential shift from proof-of-principle stage to clinical application. 

摘要翻译： 

微流控技术的最新进展使研究者能够探究免疫检查点疗法的敏感性，以确定患者对特定抗体治疗的反应。该技术的应用有助于抗体发现和个性化医疗方案的设计。多种微流控方法可在免疫学、基因组学和/或转录组学分析等流程中实现多种功能，旨在提升免疫治疗（尤其是免疫检查点阻断疗法）的疗效与覆盖范围。实现这一目标需要研究者克服当前技术层面的挑战。本文综述了应用于免疫检查点阻断治疗研究的微流控技术进展，及其从原理验证阶段向临床应用转化的潜在前景。

原文链接：

The future of microfluidics in immune checkpoint blockade