文章：

细胞内和外泌体非编码RNA对癌症进展的影响

The effects of intracellular and exosomal ncRNAs on cancer progression 

原文发布日期：2023-10-26 

英文摘要：

Altered gene expression as well as mislocalization of a gene’s encoded product (proteins or noncoding RNAs (ncRNAs)) can lead to disease and cancer formation. Multiple studies have indicated that exosomes and their contents act as cell-to-cell communicators and play a key role in cancer progression. Moreover, exosomes contain several functional molecules, including ncRNAs. NcRNAs function as master regulators to coordinate cell growth, cell motility and drug resistance. However, intracellular ncRNAs, which can be transferred to recipient cells via exosomes (exosomal ncRNAs), mediate common/distinct downstream molecules, signaling pathways and functions that are less emphasized concepts in cancer development research. In this study, by using exosomes as a model, we comprehensively discuss the current knowledge regarding (1) the functional role of ncRNAs, both their intracellular and exosomal forms, in cancer progression, (2) the possible mechanism of ncRNA incorporation into exosomes and (3) the therapeutic applications and limitations of exosomes based on current knowledge. 

摘要翻译： 

基因表达的改变以及基因编码产物（蛋白质或非编码RNA）的定位错误可导致疾病和癌症的发生。多项研究表明，外泌体及其内容物作为细胞间通讯载体，在癌症进展中起关键作用。此外，外泌体含有多种功能分子，包括非编码RNA。非编码RNA作为主调控因子协调细胞生长、细胞运动性和耐药性。然而，细胞内非编码RNA可通过外泌体转移至受体细胞（外泌体非编码RNA），介导共通/独特的下游分子、信号通路和功能——这些在癌症发展研究中尚未得到充分重视。本研究以外泌体为模型，全面探讨了当前关于以下方面的认知：（1）细胞内与非编码RNA在癌症进展中的功能作用；（2）非编码RNA被纳入外泌体的可能机制；（3）基于现有认知的外泌体治疗应用与局限性。

原文链接：

The effects of intracellular and exosomal ncRNAs on cancer progression