文章：

自杀基因策略在卵巢癌研究中的应用

Suicide gene strategies applied in ovarian cancer studies 

原文发布日期：2023-01-30 

英文摘要：

Ovarian cancer represents the most lethal gynecological malignancy among women in developed countries. Despite the recent innovations, the improvements in the 5-year survival rate have been insufficient and the management of this disease still remains a challenge. The fact that the majority of patients experience recurrent or resistant disease have substantiated the necessity of an innovative treatment. Among various strategies investigated, the recent strides made in gene delivery techniques have made gene therapy, including suicide gene strategies, a potential alternative for treating ovarian cancer. Various suicide gene candidates, which are capable of promoting cancer cell apoptosis directly after its entry or indirectly by prodrug administration, can be separated into three systems using enzyme-coding, toxin or pro-apoptotic genes. With this review, we aim to provide an overview of different suicide genes depending on therapeutic strategies, the vectors used to deliver these transgenes specifically to malignant cells, and the combined treatments of these genes with various therapeutic regimens. 

摘要翻译： 

卵巢癌是发达国家女性中最致命的妇科恶性肿瘤。尽管近期取得了诸多创新，但五年生存率的改善仍不尽如人意，该疾病的治疗管理依然面临挑战。由于大多数患者会经历疾病复发或产生耐药性，这一事实凸显了创新疗法的必要性。在研究的各种策略中，基因递送技术的最新进展使基因治疗（包括自杀基因策略）成为治疗卵巢癌的潜在替代方案。多种自杀基因候选方案能够通过直接作用或前体药物给药的间接方式促进癌细胞凋亡，可根据其作用机制分为酶编码基因系统、毒素基因系统和促凋亡基因系统三大类。本文旨在系统综述基于不同治疗策略的自杀基因、用于特异性递送这些转基因至恶性细胞的载体，以及这些基因与多种治疗方案联合应用的最新进展。

原文链接：

Suicide gene strategies applied in ovarian cancer studies