文章：

癌症治疗中的链球菌细菌成分

Streptococcal bacterial components in cancer therapy 

原文发布日期：2021-03-22 

英文摘要：

The incidence rate of cancer is steadily increasing all around the world, and there is an urgent need to develop novel and more effective treatment strategies. Recently, bacterial therapy has been investigated as a new approach to target cancer, and is becoming a serious option. Streptococcus strains are among the most common and well-studied virulent bacteria that cause a variety of human infections. Everyone has experienced a sore throat during their lifetime, or has been asymptomatically colonized by streptococci. The ability of Streptococcus bacteria to fight cancer was discovered more than 100 years ago, and over the years has undergone clinical trials, but the mechanism is not yet completely understood. Recently, several animal models and human clinical trials have been reported. Streptococcal strains can have an intrinsic anti-tumor activity, or can activate the host immune system to fight the tumor. Bacteria can selectively accumulate and proliferate in the hypoxic regions of solid tumors. Moreover, the bacteria can be genetically engineered to secrete toxins or enzymes that can specifically attack the tumors. 

摘要翻译： 

全球癌症发病率持续攀升，亟需开发新型有效的治疗策略。近年来，细菌疗法作为一种靶向癌症的新方法受到学界关注，并逐渐成为重要研究方向。链球菌属作为最常见且研究最深入的致病菌之一，可引发多种人类感染。世人一生中或曾罹患链球菌性咽炎，或曾为其无症状定植者。早在百余年前，科学家便发现链球菌具有抗癌能力，相关临床试验虽持续开展，其作用机制至今尚未完全阐明。最新研究表明，链球菌既可发挥内在抗肿瘤活性，亦能激活宿主免疫系统对抗肿瘤。这类细菌能够选择性聚集并增殖于实体瘤缺氧区域，更可通过基因工程技术改造，使其分泌特异性攻击肿瘤的毒素或酶类。

原文链接：

Streptococcal bacterial components in cancer therapy