文章：

小型胞外囊泡TGF-β在癌症进展与免疫逃逸中的作用

Small extracellular vesicle TGF-β in cancer progression and immune evasion 

原文发布日期：2023-06-21 

英文摘要：

Transforming growth factor-β (TGF-β) is a well-known cytokine that controls various processes in normal physiology and disease context. Strong preclinical and clinical literature supports the crucial roles of the TGF-β in several aspects of cancer biology. Recently emerging evidence reveals that the release of TGF-β from tumor/immune/stromal cells in small extracellular vesicles (sEVs) plays an important part in tumor development and immune evasion. Hence, this review aims to address the packaging, release, and signaling pathways of TGF-β carried in sEVs (sEV-TGF-β) in cancer, and to explore its underpinning roles in tumor development, growth, progression, metastasis, etc. We also highlight key progresses in deciphering the roles of sEV-TGF-β in subverting anti-tumor immune responses. The paper ends with a focus on the clinical significance of TGF-β carried in sEVs and draws attention to its diagnostic, therapeutic, and prognostic importance. 

摘要翻译： 

转化生长因子-β（TGF-β）是一种公认的细胞因子，在正常生理状态和疾病进程中调控多种生物学过程。大量临床前与临床研究证据表明，TGF-β在癌症生物学的多个方面发挥着关键作用。最新研究发现，肿瘤细胞/免疫细胞/基质细胞通过小型细胞外囊泡（sEVs）释放的TGF-β在肿瘤发展和免疫逃逸中具有重要作用。因此，本综述旨在探讨sEVs携带的TGF-β（sEV-TGF-β）在癌症中的包装、释放和信号传导途径，并深入分析其在肿瘤发生、生长、进展和转移等方面的潜在功能。我们重点梳理了sEV-TGF-β在破坏抗肿瘤免疫应答方面的关键研究进展，最后聚焦于sEVs携带的TGF-β的临床意义，强调其诊断价值、治疗潜力和预后重要性。

原文链接：

Small extracellular vesicle TGF-β in cancer progression and immune evasion