文章：

非编码RNA在神经母细胞瘤中的作用

Role of non-coding RNAs in neuroblastoma 

原文发布日期：2023-05-22 

英文摘要：

Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma. 

摘要翻译： 

神经母细胞瘤是儿童期最常见的颅外恶性肿瘤，起源于神经嵴。非编码RNA（ncRNA）在包括胶质瘤和胃肠道癌在内的多种癌症中发挥重要作用，这一观点已被广泛接受。它们可能调控癌症基因网络。根据最近的测序和谱分析研究，ncRNA基因在人类癌症中通过缺失、扩增、异常表观遗传或转录调控而失调。非编码RNA表达紊乱可能充当癌基因或抗肿瘤抑制基因，并诱发癌症特征性改变。肿瘤细胞可将非编码RNA分泌到外泌体中，进而转移至其他细胞影响其功能。然而，这些领域仍需进一步研究以明确其确切作用，因此本综述探讨了非编码RNA在神经母细胞瘤中的不同角色和功能。

原文链接：

Role of non-coding RNAs in neuroblastoma