文章：

MARK2在神经系统和癌症中的作用

Role of MARK2 in the nervous system and cancer 

原文发布日期：2024-02-02 

英文摘要：

Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the serine/threonine protein kinase family, phosphorylates microtubule-associated proteins, playing a crucial role in cancer and neurodegenerative diseases. This kinase regulates multiple signaling pathways, including the WNT, PI3K/AKT/mTOR (PAM), and NF-κB pathways, potentially linking it to cancer and the nervous system. As a crucial regulator of the PI3K/AKT/mTOR pathway, the loss of MARK2 inhibits the growth and metastasis of cancer cells. MARK2 is involved in the excessive phosphorylation of tau, thus influencing neurodegeneration. Therefore, MARK2 emerges as a promising drug target for the treatment of cancer and neurodegenerative diseases. Despite its significance, the development of inhibitors for MARK2 remains limited. In this review, we aim to present detailed information on the structural features of MARK2 and its role in various signaling pathways associated with cancer and neurodegenerative diseases. Additionally, we further characterize the therapeutic potential of MARK2 in neurodegenerative diseases and cancer, and hope to facilitate basic research on MARK2 and the development of inhibitors targeting MARK2. 

摘要翻译： 

微管亲和力调节激酶2（MARK2）作为丝氨酸/苏氨酸蛋白激酶家族成员，通过磷酸化微管相关蛋白在癌症和神经退行性疾病中发挥关键作用。该激酶调控WNT、PI3K/AKT/mTOR（PAM）及NF-κB等多条信号通路，可能成为连接癌症与神经系统疾病的桥梁。作为PI3K/AKT/mTOR通路的核心调控因子，MARK2缺失可抑制癌细胞生长与转移。同时MARK2参与tau蛋白的过度磷酸化过程，进而影响神经退行性病变。因此MARK2成为治疗癌症和神经退行性疾病的重要潜在靶点。尽管其作用重大，目前针对MARK2抑制剂的开发仍相对有限。本综述旨在详细阐述MARK2的结构特征及其在癌症与神经退行性疾病相关信号通路中的作用，进一步明确MARK2在神经退行性疾病和癌症治疗中的潜力，以推动MARK2基础研究及其抑制剂开发的进展。

原文链接：

Role of MARK2 in the nervous system and cancer