文章：

代谢酶翻译后修饰对肿瘤代谢的调控

Regulation of tumor metabolism by post translational modifications on metabolic enzymes 

原文发布日期：2022-08-23 

英文摘要：

Metabolic reprogramming is a hallmark of cancer development, progression, and metastasis. Several metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle, lipid metabolism, and glutamine catabolism are frequently altered to support cancer growth. Importantly, the activity of the rate-limiting metabolic enzymes in these pathways are specifically modulated in cancer cells. This is achieved by transcriptional, translational, and post translational regulations that enhance the expression, activity, stability, and substrate sensitivity of the rate-limiting enzymes. These mechanisms allow the enzymes to retain increased activity supporting the metabolic needs of rapidly growing tumors, sustain their survival in the hostile tumor microenvironments and in the metastatic lesions. In this review, we primarily focused on the post translational modifications of the rate-limiting enzymes in the glucose and glutamine metabolism, TCA cycle, and fatty acid metabolism promoting tumor progression and metastasis. 

摘要翻译： 

代谢重编程是癌症发生、进展和转移的标志性特征。为支持肿瘤生长，糖酵解、三羧酸（TCA）循环、脂质代谢和谷氨酰胺分解代谢等多种代谢通路常发生适应性改变。关键在于，这些通路中的限速代谢酶活性在癌细胞中受到特异性调控——通过转录、翻译及翻译后修饰等机制，增强限速酶的表达水平、活性强度、稳定性和底物敏感性。这些调控机制使酶类保持高活性状态，既能满足快速增殖肿瘤的代谢需求，又能支持其在恶劣肿瘤微环境及转移灶中的生存能力。本综述主要关注葡萄糖与谷氨酰胺代谢、TCA循环及脂肪酸代谢中限速酶的翻译后修饰如何促进肿瘤进展和转移。

原文链接：

Regulation of tumor metabolism by post translational modifications on metabolic enzymes