文章：

重新定义微生物代谢产物中的生物活性小分子作为革命性抗癌药物

Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents 

原文发布日期：2024-01-10 

英文摘要：

Cancer treatment remains a significant challenge due to issues such as acquired resistance to conventional therapies and the occurrence of adverse treatment-related toxicities. In recent years, researchers have turned their attention to the microbial world in search of novel and effective drugs to combat this devastating disease. Microbial derived secondary metabolites have proven to be a valuable source of biologically active compounds, which exhibit diverse functions and have demonstrated potential as treatments for various human diseases. The exploration of these compounds has provided valuable insights into their mechanisms of action against cancer cells. In-depth studies have been conducted on clinically established microbial metabolites, unraveling their anticancer properties, and shedding light on their therapeutic potential. This review aims to comprehensively examine the anticancer mechanisms of these established microbial metabolites. Additionally, it highlights the emerging therapies derived from these metabolites, offering a glimpse into the immense potential they hold for anticancer drug discovery. Furthermore, this review delves into approved treatments and major drug candidates currently undergoing clinical trials, focusing on specific molecular targets. It also addresses the challenges and issues encountered in the field of anticancer drug research and development. It also presents a comprehensive exposition of the contemporary panorama concerning microbial metabolites serving as a reservoir for anticancer agents, thereby illuminating their auspicious prospects and the prospect of forthcoming strides in the domain of cancer therapeutics. 

摘要翻译：

癌症治疗仍然是一个重大挑战，原因包括对传统疗法产生获得性耐药性以及治疗相关毒性反应等问题。近年来，研究者将目光转向微生物界，以寻找抗击这一毁灭性疾病的新型有效药物。微生物来源的次级代谢产物已被证明是具有生物活性化合物的宝贵资源，这些化合物功能多样，并显示出治疗多种人类疾病的潜力。通过对这些化合物的探索，研究人员对其作用于癌细胞的机制获得了宝贵见解。目前已对临床应用的微生物代谢物进行了深入研究，不仅揭示了其抗癌特性，更阐明了其治疗潜力。本综述旨在系统考察这些成熟微生物代谢物的抗癌机制，同时重点介绍基于这些代谢物开发的新兴疗法，展现其在抗癌药物研发领域的巨大潜力。此外，本文还深入探讨了已获批的疗法及处于临床试验阶段的主要候选药物，特别关注其特异性分子靶点，并分析了抗癌药物研发领域面临的挑战与问题。最后，本文全面阐述了微生物代谢物作为抗癌药物储备库的当代图景，从而揭示其广阔前景及其在癌症治疗领域推动未来发展的可能性。

原文链接：

Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents