文章：

基于纳米医学的癌症免疫治疗：最近的趋势和未来的展望

Nanomedicine-based cancer immunotherapy: recent trends and future perspectives

原文发布日期：2021-02-08 

英文摘要：

The combination of cancer immunotherapy with efficient functionalized nanosystems has emerged as a beneficial treatment strategy and its use has increased rapidly. The roles of stimuli-responsive nanosystems and nanomedicine-based cancer immunotherapy, a subsidiary discipline in the field of immunology, are pivotal. The present era is witnessing rapid advancements in the use of nanomedicine as a platform for investigating novel therapeutic applications and modern intelligent healthcare management strategies. The development of cancer nanomedicine has posthaste ratified the outcomes of immunotherapy to the subsequent stage in the current era of medical research. This review focuses on key findings with respect to the effectiveness of nanomedicine-based cancer immunotherapies and their applications, which include i) immune checkpoint inhibitors and nanomedicine, ii) CRISPR-Cas nanoparticles (NPs) in cancer immunotherapy, iii) combination cancer immunotherapy with core-shell nanoparticles, iv) biomimetic NPs for cancer immunotherapy, and v) CAR-T cells and cancer nanoimmunotherapy. By evaluating the state-of-the-art tools and taking the challenges involved into consideration, various aspects of the proposed nano-enabled therapeutic approaches have been discussed in this review. 

摘要翻译： 

将高效功能化纳米系统与癌症免疫疗法相结合，已成为一种优势治疗策略，其应用正迅速增长。刺激响应型纳米系统及基于纳米医学的癌症免疫疗法——这一免疫学领域的分支学科——发挥着关键作用。当前时代正见证着纳米医学作为探索新型治疗应用和现代智能健康管理策略平台的快速发展。在医学研究的新纪元中，癌症纳米医学的进展正迅速将免疫疗法的成果推向新阶段。本综述重点探讨基于纳米医学的癌症免疫疗法的关键有效性发现及其应用，包括：一）免疫检查点抑制剂与纳米医学；二）CRISPR-Cas纳米颗粒在癌症免疫治疗中的应用；三）核壳纳米颗粒联合癌症免疫治疗；四）用于癌症免疫治疗的仿生纳米颗粒；五）CAR-T细胞与癌症纳米免疫治疗。通过评估前沿技术并综合考虑现有挑战，本综述深入探讨了多种纳米化治疗策略的不同维度。

原文链接：

Nanomedicine-based cancer immunotherapy: recent trends and future perspectives