文章：

环状RNA在肿瘤顺铂耐药中作用的最新进展

Recent advances in the role of circRNA in cisplatin resistance in tumors 

原文发布日期：2025-03-27 

英文摘要：

Cancer remains a major threat to human health, with chemotherapy serving as one of the main treatment strategies to alleviate patient suffering. However, prolonged chemotherapy often leads to the development of drug resistance, complicating treatment outcomes. Cisplatin, a commonly utilized chemotherapeutic agent, demonstrates efficacy against a range of cancers but frequently encounters resistance, posing a significant challenge in tumor management and prognosis. Drug resistance not only facilitates tumor progression but also reduces survival rates, highlighting the urgent need for innovative strategies to overcome this issue. In recent years, non-coding RNAs, particularly circular RNAs (circRNAs), have gained attention in cancer therapy due to their stability and specificity. Moreover, an increasing number of studies have reported that circRNAs are involved in cisplatin resistance across various types of cancer. This paper primarily reviews the mechanisms and roles of circRNA in mediating cisplatin resistance over the past 3 years. These findings highlight circRNAs as promising therapeutic targets for overcoming cancer drug resistance. 

摘要翻译：

癌症仍是人类健康的主要威胁，化疗作为缓解患者痛苦的主要治疗策略之一，其长期应用常导致耐药性的产生，使治疗结果复杂化。顺铂作为一种常用化疗药物，对多种癌症具有疗效，但频繁出现耐药性问题，这对肿瘤治疗和预后管理构成重大挑战。耐药性不仅促进肿瘤进展，还会降低患者生存率，凸显了开发创新策略以解决这一问题的迫切性。近年来，非编码RNA，特别是环状RNA（circRNA），因其稳定性和特异性在癌症治疗领域受到关注。此外，越来越多研究报道circRNA参与多种癌症类型的顺铂耐药机制。本文主要综述近三年来circRNA介导顺铂耐药的作用机制与功能，这些发现表明circRNA有望成为克服癌症耐药性的治疗靶点。

原文链接：

Recent advances in the role of circRNA in cisplatin resistance in tumors