文章目录

放疗联合CD47阻断可引起巨噬细胞介导的体外效应

原文发布日期：2022-11-21

英文摘要：

摘要翻译：

原文链接：

文章：

放疗联合CD47阻断可引起巨噬细胞介导的体外效应

Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

原文发布日期：2022-11-21

英文摘要：

Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic form of lung cancer. CD47 blockade potently enhances the local antitumor effects of radiotherapy in preclinical models of SCLC. Notably, CD47 blockade also stimulates off-target ‘abscopal’ effects inhibiting non-irradiated SCLC tumors in mice receiving radiation. These abscopal effects are independent of T cells but require macrophages that migrate into non-irradiated tumor sites in response to inflammatory signals produced by radiation and are locally activated by CD47 blockade to phagocytose cancer cells. Similar abscopal antitumor effects were observed in other cancer models treated with radiation and CD47 blockade. The systemic activation of antitumor macrophages following radiotherapy and CD47 blockade may be particularly important in patients with cancer who suffer from metastatic disease.

摘要翻译：

放疗是治疗癌症的主要手段之一，但它并不总是能够完全消除肿瘤。我们在此将放疗与小细胞肺癌（SCLC）中特定的“别吃我的”细胞表面分子CD47阻断相结合，因为这是一种高度转移性疾病。研究发现，CD47阻断在小鼠模型的SCLC中显著增强了局部抗肿瘤效果。值得注意的是，CD47阻断还刺激了反向效应，抑制接受放疗的非照射区域SCLC肿瘤。这些反向效应独立于T细胞，但依赖巨噬细胞，后者在放疗引发的炎症反应中迁移至非照射部位并被CD47阻断局部激活以摄取癌细胞。类似地，在接受放疗和CD47阻断的其他癌症模型中也观察到这些反向抗肿瘤效应。放疗结合CD47阻断后系统性抗肿瘤巨噬细胞的激活在患有转移性疾病癌症的患者中可能特别重要。