文章：

蛋白质翻译后修饰在癌症标志调节中的作用

Protein post-translational modifications in the regulation of cancer hallmarks 

原文发布日期：2022-04-07 

英文摘要：

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylation, acetylation, ubiquitination and methylation, have been well studied, the emergence of many new modifications, such as succinylation, hydroxybutyrylation, and lactylation, introduces a new layer to protein regulation, leaving much more to be explored and wide application prospects. In this review, we will provide a broad overview of the significant roles of PTMs in regulating human cancer hallmarks through selecting a diverse set of examples, and update the current advances in the therapeutic implications of these PTMs in human cancer. 

摘要翻译：

蛋白质的翻译后修饰（PTM）作为蛋白质功能调控的主要机制，在调节多种细胞生理和病理过程中发挥着重要作用。尽管磷酸化、乙酰化、泛素化和甲基化等经典翻译后修饰已得到深入研究，但琥珀酰化、羟丁酰化和乳酸化等新型修饰的出现为蛋白质调控带来了新的维度，这些领域不仅具有广阔的研究空间，更展现出巨大的应用前景。本综述将通过选取多样化案例，全面阐述翻译后修饰在调控人类癌症特征中的重要作用，并更新这些修饰在人类癌症治疗应用中的最新进展。

原文链接：

Protein post-translational modifications in the regulation of cancer hallmarks