文章：

乳腺癌的病毒免疫治疗：前景、问题和未来方向

Viroimmunotherapy for breast cancer: promises, problems and future directions

原文发布日期：2020-12-02 

英文摘要：

Virotherapy, a strategy to use live viruses as therapeutics, is a relatively novel field in the treatment of cancer. With the advancements in molecular biology and virology, there has been a huge increase in research on cancer virotherapy. For the treatment of cancer, viruses could be used either as vectors in gene therapy or as oncolytic agents. A variety of viruses have been studied for their potential usage in gene therapy or oncolytic therapy. In this review, we discuss virotherapy with a special focus on breast cancer. Breast cancer is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current treatments are insufficient to cure metastatic breast cancer and are often associated with severe side effects that further deteriorates patients’ quality of life. Therefore, novel therapeutic approaches such as virotherapy need to be developed for the treatment of breast cancer. Here we summarize the current treatments for breast cancer and the potential use of virotherapy in the treatment of the disease. Furthermore, we discuss the use of oncolytic viruses as immunotherapeutics and the rational combination of oncolytic viruses with other therapeutics for optimal treatment of breast cancer. Finally, we outline the progress made in virotherapy for breast cancer and the shortcomings that need to be addressed for this novel therapy to move to the clinic for better treatment of breast cancer. 

摘要翻译： 

病毒疗法是一种利用活病毒作为治疗手段的策略，在癌症治疗领域中相对新兴。随着分子生物学和病毒学的进步，癌症病毒疗法的研究大幅增长。在癌症治疗中，病毒既可作为基因治疗的载体，也可作为溶瘤制剂。多种病毒已被研究其在基因治疗或溶瘤疗法中的潜在应用。本篇综述重点探讨病毒疗法在乳腺癌治疗中的应用。乳腺癌是全球女性中最常见的癌症，也是癌症相关死亡的主要原因。现有治疗手段不足以治愈转移性乳腺癌，且常伴随严重副作用，进一步降低患者生活质量。因此，需要开发如病毒疗法等新型治疗策略用于乳腺癌治疗。本文综述了目前乳腺癌的治疗方法以及病毒疗法在乳腺癌治疗中的潜在应用。此外，我们还讨论了溶瘤病毒作为免疫治疗剂的用途，以及溶瘤病毒与其他疗法合理组合以实现乳腺癌最优治疗的方案。最后，我们概述了乳腺癌病毒疗法取得的进展，以及这一新型疗法走向临床、更好地治疗乳腺癌尚需解决的不足。

原文链接：

Viroimmunotherapy for breast cancer: promises, problems and future directions