文章：

SIX3在癌症中的功能：进展与综合分析

SIX3 function in cancer: progression and comprehensive analysis 

原文发布日期：2022-06-28 

英文摘要：

The homeobox gene family encodes transcription factors that are essential for cell growth, proliferation, and differentiation, and its dysfunction is linked to tumor initiation and progression. Sine oculis homeobox (SIX) belongs to the homeobox gene family, with SIX3 being a core member. Recent studies indicate that SXI3 functions as a cancer suppressor or promoter, which is mainly dependent on SIX3’s influence on the signal pathways that promote or inhibit cancer in cells. The low expression of SIX3 in most malignant tumors was confirmed by detailed studies, which could promote the cell cycle, proliferation, migration, and angiogenesis. The recovery or upregulation of SIX3 expression to suppress cancer is closely related to the direct or indirect inhibition of the Wnt pathway. However, in some malignancies, such as esophageal cancer and gastric cancer, SIX3 is a tumor-promoting factor, and repressing SIX3 improves patients’ prognosis. This review introduces the research progress of SIX3 in tumors and gives a comprehensive analysis, intending to explain why SIX3 plays different roles in different cancers and provide new cancer therapy strategies. 

摘要翻译：

同源框基因家族编码的转录因子对细胞生长、增殖与分化至关重要，其功能失调与肿瘤发生发展密切相关。Sine oculis同源框（SIX）基因属于该家族，其中SIX3为核心成员。近期研究表明SIX3可发挥抑癌或促癌作用，这主要取决于其对细胞内癌症相关信号通路的调控方向。详细研究证实SIX3在多数恶性肿瘤中低表达，这种低表达状态可促进细胞周期进程、增殖、迁移及血管生成。通过恢复或上调SIX3表达实现抑癌作用，与直接或间接抑制Wnt通路密切相关。但在食管癌、胃癌等恶性肿瘤中，SIX3却呈现促癌因子特性，抑制SIX3可改善患者预后。本综述介绍SIX3在肿瘤中的研究进展并进行全面分析，旨在阐释其在不同癌症中发挥不同作用的原因，为癌症治疗提供新策略。

原文链接：

SIX3 function in cancer: progression and comprehensive analysis