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FUT家族在急性髓系白血病中的预后价值

Prognostic value of the FUT family in acute myeloid leukemia

原文发布日期：2019-06-17

英文摘要：

摘要翻译：

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FUT家族在急性髓系白血病中的预后价值

Prognostic value of the FUT family in acute myeloid leukemia

原文发布日期：2019-06-17

英文摘要：

Genetic abnormalities are more frequently viewed as prognostic markers in acute myeloid leukemia (AML) in recent years. Fucosylation, catalyzed by fucosyltransferases (FUTs), is a post-translational modification that widely exists in cancer cells. However, the expression and clinical implication of the FUT family (FUT1-11) in AML has not been investigated. From the Cancer Genome Atlas database, a total of 155 AML patients with complete clinical characteristics and FUT1-11 expression data were included in our study. In patients who received chemotherapy alone showed that high expression levels of FUT3, FUT6, and FUT7 had adverse effects on event-free survival (EFS) and overall survival (OS) (all P < 0.05), whereas high FUT4 expression had favorable effects on EFS and OS (all P < 0.01). However, in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) group, we only found a significant difference in EFS between the high and low FUT3 expression subgroups (P = 0.047), while other FUT members had no effect on survival. Multivariate analysis confirmed that high FUT4 expression was an independent favorable prognostic factor for both EFS (HR = 0.423, P = 0.001) and OS (HR = 0.398, P < 0.001), whereas high FUT6 expression was an independent risk factor for both EFS (HR = 1.871, P = 0.017) and OS (HR = 1.729, P = 0.028) in patients who received chemotherapy alone. Moreover, we found that patients with low FUT4 and high FUT6 expressions had the shortest EFS and OS (P < 0.05). Our study suggests that high expressions of FUT3/6/7 predict poor prognosis, high FUT4 expression indicates good prognosis in AML; FUT6 and FUT4 have the best prognosticating profile among them, but their effects could be neutralized by allo-HSCT.

摘要翻译：

近年来，遗传异常更常被视为急性髓系白血病（AML）的预后标志物。岩藻糖基化是一种由岩藻糖基转移酶（FUTs）催化的翻译后修饰过程，广泛存在于癌细胞中。然而FUT家族（FUT1-11）在AML中的表达及临床意义尚未明确。本研究从癌症基因组图谱数据库中纳入155例具有完整临床特征及FUT1-11表达数据的AML患者。在接受单纯化疗的患者中，FUT3、FUT6和FUT7高表达对无事件生存期（EFS）和总生存期（OS）均产生不利影响（均P<0.05），而FUT4高表达对EFS和OS均有积极作用（均P<0.01）。但在异基因造血干细胞移植（allo-HSCT）组中，仅发现FUT3高、低表达亚组间EFS存在显著差异（P=0.047），其他FUT成员对生存率无影响。多因素分析证实，在单纯化疗患者中，FUT4高表达是EFS（HR=0.423，P=0.001）和OS（HR=0.398，P<0.001）的独立有利预后因素，而FUT6高表达是EFS（HR=1.871，P=0.017）和OS（HR=1.729，P=0.028）的独立危险因素。此外，FUT4低表达联合FUT6高表达患者的EFS和OS最短（P<0.05）。本研究提示FUT3/6/7高表达预示AML预后不良，FUT4高表达预示良好预后；其中FUT6和FUT4具有最佳预后预测价值，但其效应可能被allo-HSCT抵消。