文章：

病毒载体：多形性胶质母细胞瘤的潜在治疗方法

Viral vector: potential therapeutic for glioblastoma multiforme

原文发布日期：2019-07-18 

英文摘要：

Glioblastoma multiforme is a highly malignant primary brain tumour found in adults and is highlighted as the most devastating among all the other grades of glioma. Well-established standard treatment methods, such as chemotherapy, radiation and surgery, have resulted in modest improvement in the survival of patients. Hence, the arduous search for novel treatments backed by advancements in molecular biology still persists. Glioblastoma has many distinctive characteristics, which makes it a potential candidate for gene therapy. Gene therapy involves the delivery of genetic material of therapeutic use into tumour cells, which produces a specific antitumour response. Moreover, viruses stimulate a vigorous cytotoxic effect, they are easily modifiable and the inherent property of horizontal transfer of genetic material makes them valuable tools for genetic engineering. In this review, we have enlisted the various viral vectors employed in gene therapy for glioblastoma. 

摘要翻译： 

多形性胶质母细胞瘤是一种高度恶性的原发性脑肿瘤，多见于成人，被公认为所有级别胶质瘤中最具破坏性的类型。尽管现有标准治疗方法（包括化疗、放射治疗和手术）已使患者生存期得到有限改善，但基于分子生物学进展的新型治疗策略探索仍持续受到广泛关注。该肿瘤具有诸多独特生物学特性，使其成为基因治疗的潜在适用对象。基因治疗通过向肿瘤细胞递送具有治疗价值的遗传物质，从而激发特异性抗肿瘤反应。病毒载体不仅能激发强烈的细胞毒效应，且具有易修饰特性，加之其固有的遗传物质水平转移能力，使之成为基因工程领域的重要工具。本文系统综述了应用于胶质母细胞瘤基因治疗的各种病毒载体。

原文链接：

Viral vector: potential therapeutic for glioblastoma multiforme