文章：

离子通道和转运体在HER2阳性乳腺癌中的病理生理作用

Pathophysiological role of ion channels and transporters in HER2-positive breast cancer 

原文发布日期：2022-01-07 

英文摘要：

The incidence of breast cancer (BC) has been increasing each year, and BC is now the most common malignant tumor in women. Among the numerous BC subtypes, HER2-positive BC can be treated with a variety of strategies based on targeting HER2. Although there has been great progress in the treatment of HER2-positive BC, recurrence, metastasis and drug resistance remain considerable challenges. The dysfunction of ion channels and transporters can affect the development and progression of HER2-positive BC, so these entities are expected to be new therapeutic targets. This review summarizes various ion channels and transporters associated with HER2-positive BC and suggests potential targets for the development of new and effective therapies. 

摘要翻译： 

乳腺癌（BC）的发病率逐年上升，现已成为女性最常见的恶性肿瘤。在众多BC亚型中，HER2阳性乳腺癌可采用多种靶向HER2的治疗策略。尽管HER2阳性乳腺癌的治疗取得了重大进展，但复发、转移和耐药性仍是巨大挑战。离子通道和转运蛋白的功能障碍会影响HER2阳性乳腺癌的发生发展，因此这些靶点有望成为新的治疗方向。本综述总结了与HER2阳性乳腺癌相关的各种离子通道和转运蛋白，并为开发新型有效疗法提出了潜在靶点。

原文链接：

Pathophysiological role of ion channels and transporters in HER2-positive breast cancer