文章：

离子通道和转运蛋白在肝细胞癌中的病理生理作用

Pathophysiological role of ion channels and transporters in hepatocellular carcinoma

原文发布日期：2024-07-24 

英文摘要：

The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed. 

摘要翻译：

肝细胞癌（HCC）在全球范围内的发病率逐年持续上升，已成为癌症相关死亡的常见原因。尽管在理解HCC发展的分子机制方面取得了重大进展，但HCC的治疗仍然是一个相当大的挑战。因此，HCC患者的生存和预后仍然极差。近年来，离子通道在疾病发病机制中的作用已成为研究热点。在正常肝组织中，离子通道和转运蛋白维持水电解质平衡及酸碱稳态。然而这些离子通道和转运蛋白的功能障碍可能导致HCC的发生与发展，因此这些离子通道和转运蛋白有望成为新的治疗靶点。本文综述了与HCC相关的离子通道和转运蛋白，并提出了潜在的新型有效治疗靶点。

原文链接：

Pathophysiological role of ion channels and transporters in hepatocellular carcinoma