文章：

SF3B1的全癌致癌特性及治疗潜力

Pan-cancer oncogenic properties and therapeutic potential of SF3B4 

原文发布日期：2025-05-20 

英文摘要：

Splicing factor 3B (SF3B) subunit 4 (SF3B4), an SF3B complex component essential for spliceosome assembly and accurate splicing, plays a major role in cancer development. However, the precise mechanism through which SF3B4 contributes to tumor growth remains unclear. Here, we demonstrate that SF3B4 is strongly expressed in patients with various cancer types and correlated with their survival. By using hepatocellular carcinoma (HCC) as a model, we reveal that SF3B4’s interactions with and regulatory influence on the checkpoint protein BUB1 are essential for appropriate cancer cell mitosis and proliferation. Our results thus demonstrate the roles of SF3B4 as both a cell-cycle regulator and an oncogenic factor in HCC, highlighting its potential as a pan-cancer therapeutic target and diagnostic biomarker. 

摘要翻译：

剪接因子3B（SF3B）亚基4（SF3B4）作为剪接体组装和精确剪接过程中不可或缺的SF3B复合体组分，在癌症发展中起主要作用。然而，SF3B4促进肿瘤生长的具体机制尚不明确。本研究通过多种癌症类型患者样本证实，SF3B4呈现高表达特征且与患者生存率显著相关。以肝细胞癌（HCC）为模型，我们发现SF3B4与检查点蛋白BUB1的相互作用及其调控功能，对癌细胞正常有丝分裂和增殖至关重要。这些结果不仅揭示了SF3B4在肝细胞癌中兼具细胞周期调控因子和致癌因子的双重角色，更凸显其作为泛癌种治疗靶点和诊断生物标志物的潜力。

原文链接：

Pan-cancer oncogenic properties and therapeutic potential of SF3B4