文章：

胃肠道癌中的P38激酶

P38 kinase in gastrointestinal cancers 

原文发布日期：2023-05-29 

英文摘要：

Gastrointestinal cancers are a leading cause of cancer morbidity and mortality worldwide with 4.2 million new cases and 3.2 million deaths estimated in 2020. Despite the advances in primary and adjuvant therapies, patients still develop distant metastases and require novel therapies. Mitogen‑activated protein kinase (MAPK) cascades are crucial signaling pathways that regulate many cellular processes, including proliferation, differentiation, apoptosis, stress responses and cancer development. p38 Mitogen Activated Protein Kinases (p38 MAPKs) includes four isoforms: p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). p38 MAPK was first identified as a stress response protein kinase that phosphorylates different transcriptional factors. Dysregulation of p38 pathways, in particular p38γ, are associated with cancer development, metastasis, autophagy and tumor microenvironment. In this article, we provide an overview of p38 and p38γ with respect to gastrointestinal cancers. Furthermore, targeting p38γ is also discussed as a potential therapy for gastrointestinal cancers. 

摘要翻译： 

胃肠道癌症是全球癌症发病和死亡的主要原因，2020年估计新增420万病例，导致320万人死亡。尽管初级和辅助治疗取得了进展，患者仍会出现远处转移，需要新型疗法。丝裂原活化蛋白激酶（MAPK）级联是调节多种细胞过程的关键信号通路，包括增殖、分化、凋亡、应激反应和癌症发展。p38丝裂原活化蛋白激酶（p38 MAPK）包含四种亚型：p38α（MAPK14）、p38β（MAPK11）、p38γ（MAPK12）和p38δ（MAPK13）。p38 MAPK最初被鉴定为一种应激反应蛋白激酶，可磷酸化不同转录因子。p38通路（尤其是p38γ）的失调与癌症发展、转移、自噬和肿瘤微环境密切相关。本文概述了p38及p38γ在胃肠道癌症中的作用，并进一步探讨靶向p38γ作为胃肠道癌症的潜在治疗策略。

原文链接：

P38 kinase in gastrointestinal cancers