文章：

癌症相关成纤维细胞：综述、进展、挑战和方向

Cancer-associated fibroblasts: overview, progress, challenges, and directions

原文发布日期：2021-03-12 

英文摘要：

Tumors are one of the main causes of death in humans. The development of safe and effective methods for early diagnosis and treatment of tumors is a difficult problem that needs to be solved urgently. It is well established that the occurrence of tumors involves complex biological mechanisms, and the tumor microenvironment (TME) plays an important role in regulating the biological behavior of tumors. Cancer-associated fibroblasts (CAFs) are a group of activated fibroblasts with significant heterogeneity and plasticity in the tumor microenvironment. They secrete a variety of active factors to regulate tumor occurrence, development, metastasis, and therapeutic resistance. Although most studies suggest that CAFs have significant tumor-promoting functions, some evidence indicates that they may have certain tumor-suppressive functions in the early stage of tumors. Current research on CAFs continues to face many challenges, and the heterogeneity of their origin, phenotype, and function is a major difficulty and hot spot. To provide new perspectives for the research on CAFs and tumor diagnosis and treatment, this review summarizes the definition, origin, biomarkers, generation mechanism, functions, heterogeneity, plasticity, subpopulations, pre-metastasis niches (PMN), immune microenvironment, and targeted therapy of CAFs, describes the research progress and challenges, and proposes possible future research directions based on existing reports. 

摘要翻译： 

肿瘤是人类死亡的主要原因之一。开发安全有效的肿瘤早期诊断与治疗方法仍是亟待解决的难题。众所周知，肿瘤的发生涉及复杂的生物学机制，而肿瘤微环境（TME）在调控肿瘤生物学行为中扮演重要角色。癌症相关成纤维细胞（CAFs）是肿瘤微环境中一群具有显著异质性和可塑性的活化纤维细胞，其通过分泌多种活性因子调控肿瘤发生、发展、转移及治疗抵抗。虽然多数研究认为CAFs具有显著促癌功能，但有证据表明其在肿瘤早期可能具有一定抑癌功能。目前针对CAFs的研究仍面临诸多挑战，其来源、表型和功能的异质性是当前研究的主要难点与热点。本文通过综述CAFs的定义、起源、生物标志物、产生机制、功能、异质性、可塑性、亚群、转移前微环境（PMN）、免疫微环境及靶向治疗等方面的研究进展，阐述当前面临的挑战，并基于现有报道提出未来可能的研究方向，以期为CAFs及肿瘤诊疗研究提供新视角。

原文链接：

Cancer-associated fibroblasts: overview, progress, challenges, and directions