文章：

BMP1过表达反映透明细胞肾细胞癌预后不良

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma 

原文发布日期：2019-06-03 

英文摘要：

Clear cell renal cell carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of renal cell carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group of cancer-related proteins in multiple pathogenesis of cancers. Currently, little is known about the prediction role of BMPs in ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information and BMP family expression data. Multivariate analysis showed that high expression of BMP1 was associated with shorter overall survival (OS) (P = 0.001), and shorter disease-free survival (DFS) (P = 0.018). Gene set enrichment analysis (GSEA) showed BMP1 was associated with epithelial–mesenchymal transition (EMT), G2M checkpoint, angiogenesis, hypoxia pathway, and Kirsten rat sarcoma viral oncogene (KRAS) signaling. Knockdown BMP1 suppressed malignancy of ccRCC in vitro and in vivo. Our results indicated that high expressions of BMP1 were poor prognostic factors and gene therapy could be an effective treatment for ccRCC. 

摘要翻译： 

透明细胞肾细胞癌（ccRCC）是肾细胞癌中死亡率、侵袭性和转移性最高的亚型。骨形态发生蛋白（BMP）家族近年来在多类癌症的发病机制中被发现与肿瘤相关。目前关于BMPs在ccRCC中的预测作用尚不明确。本研究通过筛选癌症基因组图谱肾透明细胞癌（TCGA-KIRC）数据库中具有完整临床信息及BMP家族表达数据的ccRCC患者发现：多变量分析显示BMP1高表达与较短的总生存期（OS）（P=0.001）及较短的无病生存期（DFS）（P=0.018）显著相关。基因集富集分析（GSEA）表明BMP1与上皮-间质转化（EMT）、G2M检查点、血管生成、缺氧通路以及KRAS信号通路密切相关。体内外实验证实敲低BMP1可抑制ccRCC的恶性进展。我们的研究结果表明BMP1高表达是不良预后的影响因素，而基因治疗可能成为ccRCC的有效治疗策略。

原文链接：

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma