文章：

环状RNA在结直肠癌进展中的作用：检测与治疗的新策略

Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy

原文发布日期：2024-02-09 

英文摘要：

Endogenous noncoding RNAs with a covalently closed loop are known as circular RNAs (circRNAs). Recently, published works have revealed that circRNAs, which act as microRNA sponges, are critical for the biological behavior of several kinds of malignancies, including tumor cell proliferation, apoptosis, invasion, and metastasis. Additionally, there is a significant correlation between circRNAs and tumor resistance, stage, prognosis, and size. At present, colorectal cancer (CRC) is one of the most serious malignant tumors for human health. CircRNAs could represent potential targets to use in the prevention, diagnosis, and therapy of CRC, according to many studies. To fully comprehend the role of circRNAs in the incidence and progression of CRC, this review outlines the regulatory role and mechanisms of circRNAs in CRC and assesses their potential relevance as diagnostic and treatment possibilities for CRC. Our goal is to offer meaningful biological information for clinical evaluation and decision-making process for CRC treatment. 

摘要翻译： 

内源性具有共价闭合环状结构的非编码RNA被称为环状RNA（circRNA）。近期研究显示，作为microRNA海绵的circRNAs对多种恶性肿瘤的生物学行为至关重要，包括肿瘤细胞增殖、凋亡、侵袭和转移。此外，circRNAs与肿瘤耐药性、分期、预后及大小均存在显著相关性。目前结直肠癌（CRC）是人类健康最严重的恶性肿瘤之一。多项研究表明，circRNAs可能成为CRC预防、诊断和治疗的潜在靶点。本综述通过阐述circRNAs在CRC中的调控作用与机制，评估其作为CRC诊断和治疗策略的潜在价值，旨在深入理解circRNAs在CRC发生发展中的作用，为CRC临床评估和治疗决策提供有价值的生物学信息。

原文链接：

Roles of circRNAs in the progression of colorectal cancer: novel strategies for detection and therapy