文章：

NF-κB在肿瘤增殖、迁移、侵袭和免疫逃逸中的作用

NF-κB role on tumor proliferation, migration, invasion and immune escape 

原文发布日期：2024-07-20

英文摘要：

Nuclear factor kappa-B (NF-κB) is a nuclear transcription factor that plays a key factor in promoting inflammation, which can lead to the development of cancer in a long-lasting inflammatory environment. The activation of NF-κB is essential in the initial phases of tumor development and progression, occurring in both pre-malignant cells and cells in the microenvironment such as phagocytes, T cells, and B cells. In addition to stimulating angiogenesis, inhibiting apoptosis, and promoting the growth of tumor cells, NF-κB activation also causes the epithelial–mesenchymal transition, and tumor immune evasion. Therapeutic strategies that focus on immune checkpoint molecules have revolutionized cancer treatment by enabling the immune system to activate immunological responses against tumor cells. This review focused on understanding the NF-κB signaling pathway in the context of cancer. 

摘要翻译：

核因子κB（NF-κB）是一种核转录因子，在促进炎症过程中起关键作用，长期炎症环境可能诱发癌症。NF-κB的激活对肿瘤发生和发展的初始阶段至关重要，这种激活既发生在癌前细胞中，也存在于微环境中的吞噬细胞、T细胞和B细胞等。除了刺激血管生成、抑制细胞凋亡和促进肿瘤细胞生长外，NF-κB的激活还会导致上皮-间质转化和肿瘤免疫逃逸。以免疫检查点分子为靶点的治疗策略通过激活免疫系统对肿瘤细胞的免疫反应，彻底改变了癌症治疗模式。本综述重点探讨癌症背景下NF-κB信号通路的机制。

原文链接：

NF-κB role on tumor proliferation, migration, invasion and immune escape