文章：

LncSNHGs：骨肉瘤中的新靶点

LncSNHGs: new targets in osteosarcoma

原文发布日期：2025-08-16

英文摘要：

Long non-coding RNAs (lncRNAs) have attracted significant attention for their role in tumor initiation and progression. Specifically, studying lncRNA small nucleolar RNA host genes (lncSNHGs) has opened up new possibilities for the treatment of osteosarcoma (OS). This review aims to give a thorough overview of the state of research on the biological roles, molecular mechanisms, and expression of the lncRNA SNHG family in OS. Through an extensive analysis, it is demonstrated that members of the SNHG family exhibit dysregulated expression patterns in OS. These dysregulations affect multiple oncogenic processes, including tumor proliferation, metastasis, apoptosis, autophagy, and chemotherapy resistance. The lncRNA SNHG family promises to identify novel strategies and targets for diagnosing, treating, and prognosis OS.

摘要翻译：

长链非编码RNA（lncRNA）在肿瘤发生和发展中的作用已引起广泛关注。尤其对长链非编码RNA小核仁RNA宿主基因（lncSNHG）的研究为骨肉瘤（OS）治疗开辟了新前景。本综述旨在全面阐述lncRNA SNHG家族在骨肉瘤中的生物学功能、分子机制及表达水平的研究现状。通过深入分析发现，SNHG家族成员在骨肉瘤中呈现表达失调模式，这种失调影响肿瘤增殖、转移、凋亡、自噬及化疗耐药等多种致癌过程。lncRNA SNHG家族有望为骨肉瘤的诊断、治疗和预后判断提供新策略与靶点。

原文链接：

LncSNHGs: new targets in osteosarcoma