文章：

全面理解hnRNP A1在癌症中的作用：关于其与非编码RNA结合的新视角

A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA 

原文发布日期：2022-12-02 

英文摘要：

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family (hnRNPs). hnRNP A1 is an RNA-binding protein associated with complexes active in diverse biological processes such as RNA splicing, transactivation of gene expression, and modulation of protein translation. It is overexpressed in several cancers, where it actively promotes the expression and translation of several key proteins and regulators associated with tumorigenesis and cancer progression. Interesting recent studies have focused on the RNA-binding property of hnRNP A1 and revealed previously under-explored functions of hnRNP A1 in the processing of miRNAs, and loading non-coding RNAs into exosomes. Here, we will report the recent advancements in our knowledge of the role of hnRNP A1 in the biological processes underlying cancer proliferation and growth, with a particular focus on metabolic reprogramming. 

摘要翻译： 

异质性核核糖核蛋白A1（hnRNP A1）是异质性核核糖核蛋白家族（hnRNPs）中含量最丰富且普遍表达的成员。作为一种RNA结合蛋白，hnRNP A1参与多种生物过程的复合物调控，包括RNA剪接、基因表达反式激活以及蛋白质翻译调节。该蛋白在多种癌症中过度表达，积极促进与肿瘤发生和癌症进展相关的关键蛋白及调控因子的表达与翻译。近期研究重点关注hnRNP A1的RNA结合特性，揭示了其在miRNA加工以及将非编码RNA装载到外泌体中的新功能。本文将从代谢重编程的角度重点汇报hnRNP A1在癌症增殖生长相关生物过程中作用机制的最新研究进展。

原文链接：

A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA