文章：

单细胞与空间分辨率下的软组织肉瘤：新标志物与新靶点

Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets

原文发布日期：2024-11-24 

英文摘要：

Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in connective tissues embryologically derived from the mesenchyme. Due to their rarity, crucial information about their biology is still lacking. In recent years, single-cell and spatial analyses have opened up new horizons in oncology, leading to the possibility of characterizing the internal architecture of the tumor at the single-cell and spatial levels. This review summarizes the first results acquired through these revolutionary methods for different types of STS. We discuss tumor cell populations and their evolution, interactions between tumor cells and the microenvironment, new prognostic markers, and clinically important targets. Finally, we examine the challenges presented by the single-cell and spatial omics of STS and the future perspectives in this field. 

摘要翻译：

软组织肉瘤（STS）是一类具有异质性和侵袭性的肿瘤，胚胎学上起源于间叶组织构成的结缔组织。由于其罕见性，目前仍缺乏关于其生物学特性的关键信息。近年来，单细胞与空间分析技术为肿瘤学开辟了新视野，使得在单细胞和空间层面表征肿瘤内部结构成为可能。本综述总结了通过这些革命性技术对不同类型STS取得的首批研究成果，包括肿瘤细胞群及其进化、肿瘤细胞与微环境的相互作用、新型预后标志物以及具有临床重要性的靶点。最后，我们探讨了STS单细胞与空间组学研究面临的挑战以及该领域的未来展望。

原文链接：

Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets