文章：

肿瘤中的微生物群：影响癌症发展的新因素

Microbiota in tumors: new factor influencing cancer development

原文发布日期：2024-09-28

 英文摘要：

Tumor microbiota research is a new field in oncology. With the advancement of high-throughput sequencing, there is growing evidence that a microbial community exists within tumor tissue. How these bacteria access tumor cells varies, including through the invasion of mucous membranes, the bloodstream, or the gut-organ axis. Previous literature has shown that microbes promote the development and progression of cancer through various mechanisms, such as affecting the host’s immune system, promoting inflammation, regulating metabolism, and activating invasion and transfer. The study of the tumor microbiota offers a new perspective for the diagnosis and treatment of cancer, and it holds the potential for the development of new diagnostic tools and therapies. The role of the tumor microbiota in the pathogenesis of cancer is becoming increasingly evident, and future research will continue to uncover the specific mechanisms of action of these microbes, potentially shedding light on new strategies and methods for cancer prevention and therapy. This article reviews the latest advancements in this field, including how intratumor microbes migrate, their carcinogenic mechanisms, and the characteristics of different types of tumor microbes as well as the application of relevant methods in tumor microbiota research and the clinical values of targeting tumor microbes in cancer therapy. 

摘要翻译：

肿瘤微生物组研究是肿瘤学中的一个新兴领域。随着高通量测序技术的进步，越来越多的证据表明肿瘤组织内存在微生物群落。这些细菌进入肿瘤细胞的途径多样，包括通过黏膜侵入、血液循环或肠-器官轴等途径。既往文献表明，微生物通过多种机制促进癌症的发生发展，如影响宿主免疫系统、促进炎症反应、调节代谢过程以及激活侵袭转移等。肿瘤微生物组研究为癌症诊断和治疗提供了新视角，并具有开发新型诊断工具和疗法的潜力。肿瘤微生物组在癌症发病机制中的作用日益明确，未来研究将继续揭示这些微生物的具体作用机制，可能为癌症预防和治疗提供新的策略与方法。本文综述了该领域的最新进展，包括肿瘤内微生物的迁移途径、致癌机制，以及不同类型肿瘤微生物的特征，同时探讨了相关方法在肿瘤微生物组研究中的应用以及靶向肿瘤微生物在癌症治疗中的临床价值。

原文链接：

Microbiota in tumors: new factor influencing cancer development