文章：

RNA N6-甲基腺苷（m6A）修饰在头颈部鳞状细胞癌中的分子机制及治疗潜力

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential

原文发布日期：2023-05-23 

英文摘要：

Head and neck squamous cell carcinoma ranks seventh in incidence of malignant tumours in the world. Although there are treatments including surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy, drug resistance to treatment is caused by various reasons, and the survival rate of patients remains frustrating. To overcome the bottleneck of treatment at this stage, it is urgent to identify possible diagnostic and prognostic markers. N6-methyladenosine is a methylation modification on the sixth N atom of adenine which is the most abundant epitope transcriptome modification in mammalian genes. N6-methyladenosine modification is reversible and results from the interaction among writers, erasers and readers. A large number of studies have proven that N6-methyladenosine modification has important significance in promoting the progression and treatment of tumours and have made great progress in research. In this review, we introduce how N6-methyladenosine modification promotes the occurrence and development of tumours, the mechanism of drug resistance, and new findings of N6-methyladenosine modification in radiotherapy and chemotherapy, immunotherapy, and targeted therapy. N6-methyladenosine modification provides more possibilities for improving the overall survival rate and prognosis of patients. 

摘要翻译： 

头颈部鳞状细胞癌在全球恶性肿瘤中发病率排名第七。尽管现有治疗手段包括手术、放疗、化疗、靶向治疗及免疫治疗，但由于多种原因导致的治疗耐药性问题使得患者生存率仍不理想。为突破现阶段治疗瓶颈，亟需寻找潜在的诊断与预后标志物。N6-甲基腺嘌呤是腺嘌呤第六位N原子的甲基化修饰，作为哺乳动物基因中最丰富的表位转录组修饰方式，这种可逆的修饰过程由"书写器"、"擦除器"和"阅读器"协同作用完成。大量研究证实N6-甲基腺嘌呤修饰对促进肿瘤进展和治疗具有重要作用，并已取得重大研究进展。本文综述了N6-甲基腺嘌呤修饰如何促进肿瘤发生发展、介导耐药机制，以及在放化疗、免疫治疗和靶向治疗中的新发现，为提升患者总体生存率和改善预后提供更多可能性。

原文链接：

RNA N6-methyladenosine (m6A) modification in HNSCC: molecular mechanism and therapeutic potential