文章：

膜连接RNA糖基化是展望表观转录组时代的新趋势

Membrane linked RNA glycosylation as new trend to envision epi-transcriptome epoch 

原文发布日期：2022-02-08 

英文摘要：

RNAs play several prominent roles in the cellular environment ranging from structural, messengers, translators, and effector molecules. RNA molecules while performing these roles are associated with several chemical modifications occurring post-transcriptionally, responsible for these supporting vital functions. The recent documentation of surface RNA modification with sialic acid residues has sparked advancement to the framework of RNA modifications. Glycan modification of surface RNA which was previously known to modify only proteins and lipids has opened new vistas to explore how these surface RNA modifications affect the cellular responses and phenotype. This paradigm shift in RNA biology with a vision of “glycans being all over the cells” has posed the field with a repertoire of questions and has given headway to the RNA world hypothesis. The review provides a comprehensive overview of glycoRNA discovery with a conceptual understanding of its previous underlying discoveries and their biological consequences with possible insights into the dynamic influence of this modification on their molecular versatility deciding cancer-immunology fate with potential implications of these glycosylation in cellular interaction, signaling, immune regulation, cancer evasion and proliferation. 

摘要翻译： 

RNA在细胞环境中扮演多种重要角色，包括作为结构分子、信使、翻译器和效应分子。RNA分子在执行这些功能时，会伴随多种转录后化学修饰，这些修饰对其维持关键功能至关重要。近期关于RNA表面被唾液酸残基修饰的记载，推动了RNA修饰研究框架的进展。表面RNA的聚糖修饰（此前仅知存在于蛋白质和脂质）为探索这些修饰如何影响细胞反应和表型开辟了新视角。这种以"聚糖遍布细胞"为视角的RNA生物学范式转变，为该领域带来了一系列新问题，并为RNA世界假说提供了推进依据。本综述全面概述了糖RNA的发现过程，从概念层面阐释了其前期基础发现及其生物学效应，并深入探讨了此类修饰如何动态影响分子多功能性——从而决定癌症-免疫学命运，以及这些糖基化修饰在细胞互作、信号传导、免疫调节、癌症逃逸和增殖中的潜在作用。

原文链接：

Membrane linked RNA glycosylation as new trend to envision epi-transcriptome epoch