文章：

通过N6-甲基腺苷RNA修饰调控肿瘤免疫微环境

Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification 

原文发布日期：2024-06-04 

英文摘要：

N6-methyladenosine (m6A), a posttranscriptional regulatory mechanism, is the most common epigenetic modification in mammalian mRNA. M6A modifications play a crucial role in the developmental network of immune cells. The expression of m6A-related regulators often affects carcinogenesis and tumour suppression networks. In the tumour microenvironment, m6A-modified enzymes can affect the occurrence and progression of tumours by regulating the activation and invasion of tumour-associated immune cells. Immunotherapy, which utilises immune cells, has been demonstrated to be a powerful weapon in tumour treatment and is increasingly being used in the clinic. Here, we provide an updated and comprehensive overview of how m6A modifications affect invasive immune cells and their potential role in immune regulation. In addition, we summarise the regulation of epigenetic regulators associated with m6A modifications in tumour cells on the antitumour response of immune cells in the tumour immune microenvironment. These findings provide new insights into the role of m6A modifications in the immune response and tumour development, leading to the development of novel immunotherapies for cancer treatment. 

摘要翻译：

N6-甲基腺苷（m6A）作为一种转录后调控机制，是哺乳动物mRNA中最常见的表观遗传修饰。m6A修饰在免疫细胞的发育网络中起着关键作用。m6A相关调节因子的表达常影响癌变和抑癌网络。在肿瘤微环境中，经m6A修饰的酶可通过调控肿瘤相关免疫细胞的活化与侵袭，影响肿瘤的发生与发展。利用免疫细胞的免疫疗法已被证明是肿瘤治疗的有力武器，并日益广泛应用于临床。本文最新综述了m6A修饰如何影响侵袭性免疫细胞及其在免疫调控中的潜在作用，同时总结了肿瘤免疫微环境中m6A相关表观遗传调节因子对免疫细胞抗肿瘤反应的调控机制。这些发现为理解m6A修饰在免疫应答和肿瘤进展中的作用提供了新视角，进而推动癌症治疗新型免疫疗法的开发。

原文链接：

Manipulating the tumour immune microenvironment by N6-methyladenosine RNA modification