文章：

枸杞糖肽靶向PER2通过下调SREBP1c抑制胶质母细胞瘤脂肪生成

Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c 

原文发布日期：2023-04-17 

英文摘要：

Lycium barbarum polysaccharide (LBP) is a substance with various biological activities extracted from Lycium barbarum. LbGPs are peptidoglycans with a short peptide backbone and a complex, branched glycan moiety, which is further extracted and isolated from LBPs. Previous studies have shown that LbGP can inhibit cancer cell growth, but its specific mechanism is not completely clear. In this study, we found that LbGP could inhibit the proliferation of glioma cells and promote the expression of period 2 (PER2) through the PKA-CREB pathway. In addition, LbGP could inhibit the de novo synthesis of lipids by downregulating SREBP1c and its target genes, which depended on the expression of PER2. Moreover, PER2 negatively regulated the expression of SREBP1c via suppressing PI3K/AKT/mTOR pathway. In summary, LbGP may upregulate the expression of PER2 to reduce the expression of SREBP1c, inhibit lipid synthesis in glioblastoma, and inhibit glioblastoma cell proliferation. This study provides an alternative drug for the treatment of glioma and elucidates its potential mechanism. 

摘要翻译： 

枸杞多糖（LBP）是从枸杞中提取的具有多种生物活性的物质。LbGPs是从LBP中进一步提取分离得到的肽聚糖，其具有短肽骨架和复杂分支的聚糖结构。既往研究表明LbGP能抑制癌细胞生长，但其具体机制尚未完全明确。本研究发现LbGP可通过PKA-CREB通路抑制胶质瘤细胞增殖并促进周期蛋白2（PER2）的表达。此外，LbGP能通过下调SREBP1c及其靶基因抑制脂质从头合成，这一过程依赖于PER2的表达。更重要的是，PER2通过抑制PI3K/AKT/mTOR通路负向调控SREBP1c的表达。综上所述，LbGP可能通过上调PER2表达来降低SREBP1c表达，从而抑制胶质母细胞瘤中的脂质合成及细胞增殖。本研究为胶质瘤治疗提供了替代药物并阐明了其潜在作用机制。

原文链接：

Lycium barbarum glycopeptide targets PER2 to inhibit lipogenesis in glioblastoma by downregulating SREBP1c