文章：

结直肠癌相关炎症基因MicroRNA结合位点多态性：文献回顾和生物信息学分析

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis

原文发布日期：2020-03-23 

英文摘要：

Inflammation, among environmental risk factors, is one of the most important contributors to colorectal cancer (CRC) development. In this way, studies revealed that the incidence of CRC in inflammatory bowel disease patients is up to 60% higher than the general population. MicroRNAs (miRNAs), small noncoding RNA molecules, have attracted excessive attention due to their fundamental role in various aspects of cellular biology, such as inflammation by binding to the 3′-untranslated regions (3′-UTR) of pro and anti-inflammatory genes. Based on multiple previous studies, SNPs at 3′-UTR can affect miRNA recognition elements by changing the thermodynamic features and secondary structure. This effect can be categorized, based on the number of changes, into four groups, including break, decrease, create, and enhance. In this paper, we will focus on functional variants in miRNA binding sites in inflammatory genes, which can modulate the risk of CRC by both investigating previous studies, regarding miRSNPs in inflammatory genes associated with CRC and recruiting in silico prediction algorithms to report putative miRSNPs in 176 inflammatory genes. In our analysis, we achieved 110 miRSNPs in 3′-UTR of 67 genes that seem good targets for future researches. 

摘要翻译： 

在环境风险因素中，炎症是结直肠癌（CRC）发生最重要的促进因素之一。研究表明，炎症性肠病患者的结直肠癌发病率比普通人群高出60%。微小RNA（miRNA）作为小型非编码RNA分子，因其通过结合促炎和抗炎基因的3'-非翻译区（3'-UTR），在炎症等细胞生物学多方面发挥重要作用而受到广泛关注。既往多项研究表明，3'-UTR区域的单核苷酸多态性（SNP）可通过改变热力学特征和二级结构影响miRNA识别元件。根据改变类型的不同，这种影响可分为四类：破坏、减弱、创建和增强。本文通过综述炎症基因中与CRC相关的miRSNP既往研究，并结合计算机预测算法筛选176个炎症基因中潜在的miRSNP，重点探讨miRNA结合位点的功能变异如何调节CRC风险。通过分析，我们在67个基因的3'-UTR区域中确定了110个miRSNP，这些位点有望成为未来研究的重要靶点。

原文链接：

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis