文章：

人类癌症中与kras相关的长链非编码RNA

KRAS-related long noncoding RNAs in human cancers 

原文发布日期：2021-09-06 

英文摘要：

KRAS is one of the most widely prevalent proto-oncogenes in human cancers. The constitutively active KRAS oncoprotein contributes to both tumor onset and cancer development by promoting cell proliferation and anchorage-independent growth in a MAPK pathway-dependent manner. The expression of microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, while long noncoding RNAs (lncRNAs) can act as regulators of the miRNAs targeting KRAS oncogene in different cancers and have gradually become a focus of research in recent years. In this review article, we summarize recent advances in the research on lncRNAs that have sponging effects on KRAS-targeting miRNAs as crucial mediators of KRAS expression in different cell types and organs. A deeper understanding of lncRNA function in KRAS-driven cancers is of major fundamental importance and will provide a valuable clinical tool for the diagnosis, prognosis, and eventual treatment of cancers. 

摘要翻译：

KRAS是人类癌症中最普遍存在的原癌基因之一。组成型活化的KRAS癌蛋白通过MAPK通路依赖性方式促进细胞增殖和锚定非依赖性生长，从而参与肿瘤发生和癌症发展。已知microRNA（miRNA）与KRAS癌基因在多种癌症中存在表达失调现象，而长链非编码RNA（lncRNA）可作为靶向KRAS癌基因的miRNA调控因子在不同癌症中发挥作用，近年来逐渐成为研究热点。本文综述了具有吸附KRAS靶向miRNA功能的lncRNAs研究新进展，这些lncRNA是不同细胞类型和器官中KRAS表达的关键介质。深入理解lncRNA在KRAS驱动癌症中的功能具有重大基础意义，并将为癌症的诊断、预后及最终治疗提供有价值的临床工具。

原文链接：

KRAS-related long noncoding RNAs in human cancers