文章：

关键趋化因子直接免疫细胞在实体瘤中的迁移

Key chemokines direct migration of immune cells in solid tumors 

原文发布日期：2021-02-18 

英文摘要：

Immune cell infiltration into solid tumors, their movement within the tumor microenvironment (TME), and interaction with other immune cells are controlled by their directed migration towards gradients of chemokines. Dysregulated chemokine signaling in TME favors the growth of tumors, exclusion of effector immune cells, and abundance of immunosuppressive cells. Key chemokines directing the migration of immune cells into tumor tissue have been identified. In this review, we discuss well-studied chemokine receptors that regulate migration of effector and immunosuppressive immune cells in the context of cancer immunology. We discuss preclinical models that have described the role of respective chemokine receptors in immune cell migration into TME and review preclinical and clinical studies that target chemokine signaling as standalone or combination therapies. 

摘要翻译：

免疫细胞向实体瘤内的浸润、其在肿瘤微环境（TME）中的运动以及与其他免疫细胞的相互作用，受其趋化因子梯度导向迁移的调控。TME中趋化因子信号传导的失调会促进肿瘤生长、排斥效应免疫细胞并富集免疫抑制细胞。目前已鉴定出引导免疫细胞向肿瘤组织迁移的关键趋化因子。本综述重点探讨癌症免疫学背景下调控效应性与免疫抑制性免疫细胞迁移的经典趋化因子受体，阐述临床前模型中不同趋化因子受体在免疫细胞向TME迁移中的作用，并综述靶向趋化因子信号通路作为单一或联合疗法的临床前及临床研究进展。

原文链接：

Key chemokines direct migration of immune cells in solid tumors