文章：

抗增殖性肿瘤抑制细胞因子强制的内在S期检查点

Intrinsic S phase checkpoint enforced by an antiproliferative oncosuppressor cytokine 

原文发布日期：2021-11-04 

英文摘要：

The cell cycle is strictly programmed with control mechanisms that dictate order in cell cycle progression to ensure faithful DNA replication, whose deviance may lead to cancer. Checkpoint control at the G1/S, S/G2 and G2/M portals have been defined but no statutory time-programmed control for securing orderly transition through S phase has so far been identified. Here we report that in normal cells DNA synthesis is controlled by a checkpoint sited within the early part of S phase, enforced by the βGBP cytokine an antiproliferative molecule otherwise known for its oncosuppressor properties that normal cells constitutively produce for self-regulation. Suppression of active Ras and active MAPK, block of cyclin A gene expression and suppression of CDK2-cyclin A activity are events which while specific to the control of a cell cycle phase in normal cells are part of the apoptotic network in cancer cells. 

摘要翻译： 

细胞周期受到严格程序化的控制机制调控，这些机制通过规定周期进程顺序来确保DNA的忠实复制，其偏差可能导致癌症。目前G1/S期、S/G2期和G2/M期检查点控制已被明确，但迄今为止尚未发现确保持续有序通过S期的法定时间程序化控制机制。本研究发现：在正常细胞中，DNA合成受到位于S期早期阶段的检查点控制，该检查点由βGBP细胞因子强制执行——这种具有抑癌特性的抗增殖分子是正常细胞为维持自我调控而持续产生的。活性Ras与MAPK的抑制、细胞周期蛋白A基因表达的阻断以及CDK2-细胞周期蛋白A活性的抑制，这些在正常细胞中特异性调控细胞周期的事件，在癌细胞中则成为凋亡网络的组成部分。

原文链接：

Intrinsic S phase checkpoint enforced by an antiproliferative oncosuppressor cytokine