文章：

人类内源性逆转录病毒（HERVs）与胶质母细胞瘤的风险及预后相关

Human endogenous retroviruses (HERVs) associated with glioblastoma risk and prognosis 

原文发布日期：2025-05-19 

英文摘要：

Emerging evidence suggests expression from human endogenous retrovirus (HERV) loci likely contributes to, or is a biomarker of, glioblastoma multiforme (GBM) disease progression. However, the relationship between HERV expression and GBM malignant phenotype is unclear. Applying several in silico analyses based on data from The Cancer Genome Atlas (TCGA), we derived a locus-specific HERV transcriptome for glioma that revealed 211 HERVs significantly dysregulated in the comparisons of GBM vs. normal brain (NB), GBM vs. low-grade glioma (LGG), and LGG vs. NB. Our analysis supported development of a unique HERV scoring algorithm that segregated GBM, LGG, and NB. Interestingly, lower HERV scores showed correlation with lower survival in GBM. However, HERV scores were less robust in predicting LGG survival or LGG progression to GBM. Functional prediction analysis linked the 211 HERV loci with 18 voltage-gated potassium channel genes. The functional link between dysregulated HERVs and specific potassium channel genes may contribute to better understanding of GBM pathogenesis, disease progression, and possibly drug resistance. 

摘要翻译：

新近证据表明，人类内源性逆转录病毒（HERV）基因座的表达可能促进多形性胶质母细胞瘤（GBM）的疾病进展，或可作为其生物标志物。然而，HERV表达与GBM恶性表型之间的关系尚不明确。通过基于癌症基因组图谱（TCGA）数据的多项计算机分析，我们推导出胶质瘤的特异性HERV转录组定位图谱，发现在GBM与正常脑组织（NB）、GBM与低级别胶质瘤（LGG）以及LGG与NB的对比中，共有211个HERV呈现显著失调。我们的分析支持开发了一种独特的HERV评分算法，能够区分GBM、LGG和NB。值得注意的是，较低的HERV评分与GBM患者较低生存率相关。但该评分在预测LGG生存率或LGG向GBM进展方面的效力较弱。功能预测分析将211个HERV基因座与18个电压门控钾离子通道基因相关联。这种失调HERV与特定钾离子通道基因之间的功能联系，可能有助于更好地理解GBM的发病机制、疾病进展及可能的耐药性。

原文链接：

Human endogenous retroviruses (HERVs) associated with glioblastoma risk and prognosis