文章：

IFITM3高表达预示急性髓系白血病不良预后

High IFITM3 expression predicts adverse prognosis in acute myeloid leukemia 

原文发布日期：2019-03-29 

英文摘要：

Acute myeloid leukemia (AML) is a malignancy caused by the uncontrolled and dysregulated clonal expansion of abnormal myeloid primordial cells. In general, the prognosis of AML remains poor despite new discoveries in its pathogenesis and treatment. It is crucial to find early and sensitive biomarkers and continue to explore active targeted treatments. Interferon-induced transmembrane protein (IFITM) family is an important part of the interferon signaling pathway and participate in the regulation of immune cell signaling, adhesion, cancer, and liver cell migration. However, the clinical and prognostic value of the IFITM family in AML has rarely been studied. We screened The Cancer Genome Atlas database and found 155 AML patients with IFITM family (IFITM1–5) expression data. In patients who only received chemotherapy, those with high IFITM3 expression had significantly shorter event-free survival (EFS) and overall survival (OS) than patients with low expression (all P < 0.05). Multivariate analysis demonstrated that high IFITM3 expression was an independent risk factor for EFS and OS in patients only received chemotherapy (all P < 0.05). In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, all IFITM members had no impact on either EFS or OS. In conclusion, our study elucidated that high IFITM3 expression could be an adverse prognostic factor for AML, whose effect might be overcome by allo-HSCT. 

摘要翻译： 

急性髓系白血病（AML）是一种由异常髓系祖细胞不受控制和失调的克隆扩增引起的恶性肿瘤。总体而言，尽管在其发病机制和治疗方面有新发现，AML的预后仍然较差。寻找早期敏感的生物标志物并继续探索有效的靶向治疗至关重要。干扰素诱导跨膜蛋白（IFITM）家族是干扰素信号通路的重要组成部分，参与免疫细胞信号传导、粘附、癌症和肝细胞迁移的调控。然而，IFITM家族在AML中的临床和预后价值研究甚少。我们筛选了癌症基因组图谱数据库，发现155名具有IFITM家族（IFITM1-5）表达数据的AML患者。在仅接受化疗的患者中，IFITM3高表达患者的无事件生存期（EFS）和总生存期（OS）均显著短于低表达患者（所有P < 0.05）。多变量分析表明，在仅接受化疗的患者中，IFITM3高表达是EFS和OS的独立危险因素（所有P < 0.05）。然而，在接受异基因造血干细胞移植（allo-HSCT）的患者中，所有IFITM成员对EFS或OS均无影响。总之，我们的研究阐明IFITM3高表达可能是AML的不良预后因素，而其影响可能通过allo-HSCT克服。

原文链接：

High IFITM3 expression predicts adverse prognosis in acute myeloid leukemia