文章：

胶质瘤发病相关蛋白1在肿瘤细胞中具有双重功能

Glioma pathogenesis-related protein 1 performs dual functions in tumor cells 

原文发布日期：2021-03-19 

英文摘要：

Glioma pathogenesis-related protein 1 (GLIPR1) was identified as an oncoprotein in some cancer types including gliomas, breast cancers, melanoma cancers, and Wilms tumors, but as a tumor suppressor in some other types of cancers, such as prostate cancers, lung cancers, bladder cancers, and thyroid cancers. In gliomas, GLIPR1 promotes the migration and invasion of glioma cells by interaction with the actin polymerization regulator Neural Wiskott–Aldrich syndrome protein (N-WASP) and then abolishes the negative effects of Heterogeneous nuclear ribonuclear protein K (hnRNPK). In prostate cancers, high levels of GLIPR1 induce apoptosis and destruction of oncoproteins. In lung cancers, overexpression of GLIPR1 inhibits the growth of lung cancer cells partially through inhibiting the V-ErbB avian erythroblastic leukemia viral oncogene homolog3 (ErbB3) pathway. However, the mechanisms that GLIPR1 performs its function in other tumors still remain unclear. The tumor suppressing role of GLIPR1 has been explored to the cancer treatment. The adenoviral vector-mediated Glipr1 (AdGlipr1) gene therapy and the GLIPR1-transmembrane domain deleted (GLIPR1-ΔTM) protein therapy both showed antitumor activities and stimulated immune response in prostate cancers. Whether GLPIR1 can be used to treat other tumors is an important topic to be explored. Among which, whether GLPIR1 can be used to treat lung cancer by atomizing inhalation is the key topic we care about. If it does, this therapy has a wide application prospect and is a great progression in lung cancer treatment. 

摘要翻译： 

胶质瘤病理发生相关蛋白1（GLIPR1）在包括胶质瘤、乳腺癌、黑色素瘤和肾母细胞瘤在内的多种癌症中被鉴定为致癌蛋白，但在前列腺癌、肺癌、膀胱癌和甲状腺癌等其他类型癌症中却发挥肿瘤抑制作用。在胶质瘤中，GLIPR1通过与肌动蛋白聚合调节因子神经Wiskott-Aldrich综合征蛋白（N-WASP）相互作用，消除异质核核糖核蛋白K（hnRNPK）的负面效应，从而促进胶质瘤细胞的迁移与侵袭。而在前列腺癌中，高表达GLIPR1可诱导细胞凋亡并破坏致癌蛋白。在肺癌中，GLIPR1的过表达部分通过抑制V-ErbB鸟类成红细胞增多症病毒致癌基因同源物3（ErbB3）通路来抑制肺癌细胞生长。然而GLIPR1在其他肿瘤中的作用机制仍不明确。

目前GLIPR1的肿瘤抑制功能已被探索用于癌症治疗。腺病毒载体介导的Glipr1（AdGlipr1）基因疗法以及跨膜结构域缺失的GLIPR1（GLIPR1-ΔTM）蛋白疗法在前列腺癌中均显示出抗肿瘤活性并能激发免疫应答。GLIPR1能否用于治疗其他肿瘤是值得探索的重要课题，其中通过雾化吸入方式治疗肺癌的可能性是我们关注的核心方向。若该疗法可行，将具有广阔的应用前景，并成为肺癌治疗领域的重大进展。

原文链接：

Glioma pathogenesis-related protein 1 performs dual functions in tumor cells