文章：

FYN-TRAF3IP2诱导NF-κB信号驱动的外周t细胞淋巴瘤

FYN–TRAF3IP2 induces NF-κB signaling-driven peripheral T-cell lymphoma 

原文发布日期：2021-01-13 

英文摘要：

Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma not otherwise specified (PTCL, NOS) have poor prognosis and, in most cases, lack driver actionable targets for directed therapies. Here we identify FYN–TRAF3IP2 as a recurrent oncogenic gene fusion in AITL and PTCL, NOS tumors. Mechanistically, we show that FYN–TRAF3IP2 leads to aberrant NF-κB signaling downstream of T-cell antigen receptor activation. Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induces NF-κB-driven T-cell transformation in mice and cooperates with loss of the Tet2 tumor suppressor in PTCL development. Moreover, abrogation of NF-κB signaling in FYN–TRAF3IP2-induced tumors with IκB kinase inhibitors delivers strong anti-lymphoma effects in vitro and in vivo. These results demonstrate an oncogenic and pharmacologically targetable role for FYN–TRAF3IP2 in PTCLs and call for the clinical testing of anti-NF-κB targeted therapies in these diseases. 

摘要翻译：

角质化免疫性淋巴瘤(AITL)和未另有指定的外围T细胞淋巴瘤(PTCL,NOS)，这两种淋巴瘤的预后较差，在大多数病例中缺乏可靶向治疗的目标。在这项研究中，我们发现FYN-TRAF3IP2基因融合是AITL和PTCL,NOS肿瘤中一种具有高频率性转移性原癌基因。 

原文链接：

https://www.nature.com/articles/s43018-020-00161-w