文章：

胶质母细胞瘤相关巨噬细胞在胶质母细胞瘤中的功能、机制及治疗进展

Glioblastoma-associated macrophages in glioblastoma: from their function and mechanism to therapeutic advances

原文发布日期：2025-04-30 

英文摘要：

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults and has high mortality rates worldwide. GBM progression, treatment, and prognosis are influenced by the tumor microenvironment (TME), which includes immune, stromal, and tumor cells. Among them, glioblastoma-associated macrophages (GAMs) act as key regulators of GBM pathobiology. GAMs exhibit remarkable plasticity, as they can exhibit both protumor and antitumor effects. However, their function is determined by polarization and the TME. In this review, we provide a comprehensive overview of the current understanding of the biology of GAMs in GBM, including their origins, phenotypic diversity, and functional roles. We discuss the intricate crosstalk between GAMs and tumor cells, as well as other immune and stromal components, and highlight the mechanisms underlying GAM-mediated tumor progression, invasion, angiogenesis, and immune system evasion. Furthermore, we explore the therapeutic implications of targeting GAMs in GBM and discuss emerging strategies aimed at reprogramming GAMs toward an antitumorigenic phenotype or selectively depleting protumorigenic subsets. The final aim is to develop innovative therapeutic approaches that disrupt GBMs. By leveraging our increased understanding of GAM biology, we lay the foundation for transformative advances in GBM treatment to improve patient prognosis. 

摘要翻译：

多形性胶质母细胞瘤（GBM）是成人中最具侵袭性的原发性脑肿瘤，在全球范围内具有高死亡率。GBM的进展、治疗及预后受到肿瘤微环境（TME）的影响，该环境包括免疫细胞、基质细胞和肿瘤细胞。其中，胶质母细胞瘤相关巨噬细胞（GAMs）是GBM病理生物学中的关键调节因子。GAMs表现出显著的可塑性，既能发挥促肿瘤作用，也能产生抗肿瘤效应。然而，其功能由极化和TME共同决定。本文综述了当前对GAMs在GBM中生物学的全面认识，包括其起源、表型多样性和功能作用。我们探讨了GAMs与肿瘤细胞以及其他免疫和基质组分之间复杂的相互作用，并重点阐述了GAM介导的肿瘤进展、侵袭、血管生成和免疫系统逃逸的机制。此外，我们探索了靶向GAMs在GBM治疗中的意义，讨论了旨在将GAMs重编程为抗肿瘤表型或选择性清除促肿瘤亚群的新兴策略。最终目标是开发突破性的治疗方法以瓦解GBM。通过利用对GAM生物学日益深入的理解，我们为GBM治疗的变革性进展奠定基础，以改善患者预后。

原文链接：

Glioblastoma-associated macrophages in glioblastoma: from their function and mechanism to therapeutic advances