文章：

p53调控的lncRNA在癌症中的作用：从增殖、转移到治疗

p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy 

原文发布日期：2023-09-07 

英文摘要：

Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein modification and RNA-protein complexes. LncRNA dysregulation is frequently associated with a variety of biological functions and human diseases including cancer. The p53 network is a key tumor-suppressive mechanism that transcriptionally activates target genes to suppress cellular proliferation in human malignancies. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. In this review, we summarize the current knowledge of lncRNAs in p53-relevant functions and provide an overview of how these altered lncRNAs contribute to tumor initiation and progression. We also discuss the association between lncRNA and up- or downstream genes of p53. These findings imply that lncRNAs can help identify cellular vulnerabilities that may prove to be promising potential biomarkers and therapeutic targets for cancer treatment. 

摘要翻译： 

长链非编码RNA（lncRNA）已被确认为通过转录、翻译、蛋白质修饰及RNA-蛋白质复合体等多种机制发挥核心基因调控作用。LncRNA的失调常与多种生物学功能及人类疾病（包括癌症）密切相关。p53网络是关键抑癌机制，通过转录激活靶基因抑制人类恶性肿瘤中的细胞增殖。最新研究表明lncRNA在p53信号通路中扮演重要角色。本文综述了当前对lncRNA在p53相关功能中的认知，并概述这些异常lncRNA如何促进肿瘤发生与发展。同时探讨了lncRNA与p53上下游基因的关联机制。这些发现表明lncRNA有助于识别细胞脆弱性，可能成为癌症治疗中具有潜力的生物标志物和治疗靶点。

原文链接：

p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy