文章：

微小RNA-301a在人类癌症中的多面角色：从生物标志物潜力到治疗靶点

Multifaceted role of microRNA-301a in human cancer: from biomarker potential to therapeutic targeting

原文发布日期：2024-09-24 

英文摘要：

With the growing data on microRNA (miRNA) expression in tissues and circulation, there is increasing evidence for the potential of microRNAs to serve as biomarkers in cancer diagnosis and prognosis, as well as novel therapeutic targets. The expression level of miRNA-301a (miR-301a) is altered in a wide range of human tumor types, and numerous studies have revealed the roles of miR-301a in tumorigenesis and tumor progression. Herein, we comprehensively summarize, compare, and contrast the research advancements on the role of miR-301a in different cancers. Differential expression patterns of miR-301a in tissues and biofluids are implicated in cancer diagnosis, treatment response, and prognosis. MiR-301a modulates the expression of multiple genes, other noncoding RNAs, and signaling cascade via direct or indirect regulation in human cancer proliferation, migration, invasion, angiogenesis, and radio- or chemotherapy resistance. Cancer cell-associated miR-301a affects the tumor microenvironment through the alteration of immune function and cancer metabolism. These findings highlight the functional roles, clinical implications, and therapeutic relevance of miR-301a in various human cancers. 

摘要翻译：

随着关于组织和循环中microRNA（miRNA）表达的数据日益丰富，越来越多的证据表明microRNA有潜力作为癌症诊断和预后的生物标志物以及新型治疗靶点。miR-301a的表达水平在多种人类肿瘤类型中发生改变，大量研究揭示了miR-301a在肿瘤发生和进展中的作用。本文全面总结、比较并对比了miR-301a在不同癌症中作用的研究进展。miR-301a在组织和生物液体中的差异表达模式与癌症诊断、治疗反应及预后密切相关。通过直接或间接调控，miR-301a可影响人类癌症增殖、迁移、侵袭、血管生成以及放化疗抗性中多个基因、其他非编码RNA和信号通路的表达。癌细胞相关miR-301a通过改变免疫功能和癌症代谢影响肿瘤微环境。这些发现凸显了miR-301a在多种人类癌症中的功能作用、临床意义和治疗相关性。

原文链接：

Multifaceted role of microRNA-301a in human cancer: from biomarker potential to therapeutic targeting